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Important in plants and animals molecule write on the white board
Xapramoba N
10.1017/S0007114518002921 15 De VosW
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A number of pathogenic variants at disparate loci have been associated with this syndrome, including HPS1 , HPS3 , HPS4 , HPS5 , HPS6 , HPS7 ( DTNBP1 ), HPS8 ( BLOC1S3 ), and HPS9 ( PLDN ).[113-120] Pigmentation characteristics can vary significantly in this disorder, particularly among those with HPS1 pathogenic variants, and patients report darkening of the skin and hair as they age
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